Visual Studio not auto-building on run

Right-click on configuration manager and check to see if build is checked for project in question
Also in Tools > Options > Projects and Solutions > On run when projects are out of date > Always Build

Thanks to
http://superuser.com/questions/135627/visual-studio-not-auto-building-when-i-press-the-debug-button

Addendum 17-8-2011
If above not succeeded then keep these options, but also do a Clean (of solution -works or of project -not tested)

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